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EVIDENCE REVIEW

Psychosocial interventions: a meta-analysis

Odds ratios for relapse and event rates across psychosocial interventions for psychosis, compared with treatment as usual at ≤6 months, 12 months, and beyond 12 months.

Visual representation (forest plot)

Intervention

OR (95% CI)

Event rate

Favours experimentalFavours treatment as usual

Family intervention

0.63 (0.37-1.08)

0.35 (0.24-0.52)

16% (11-22)

Relapse prevention programme

0.39 (0.27-0.58)

0.41 (0.17-1.00)

0.33 (0.14-0.79)

15% (7-30)

Cognitive training

0.22 (0.05-0.88)

0.62 (0.10-3.99)

0.31 (0.07-1.40)

14% (4-43)

Cognitive behavioural therapy

0.34 (0.09-1.27)

0.57 (0.27-1.19)

0.45 (0.27-0.75)

20% (13-29)

Acceptance and commitment therapy

1.03 (0.54-1.97)

Supportive therapy

0.39 (0.13-1.16)

0.39 (0.12-1.27)

18% (6-41)

Family psychoeducation

0.53 (0.24-1.16)

22% (12-38)

Integrated intervention

1.07 (0.43-2.68)

0.68 (0.40-1.15)

0.56 (0.39-0.82)

23% (17-31)

Social skills training

0.42 (0.24-0.76)

0.45 (0.31-0.65)

0.62 (0.44-0.87)

25% (19-32)

Psychoeducation

0.49 (0.27-0.88)

3.55 (0.33-38.42)

0.62 (0.30-1.29)

25% (14-41)

Telemedicine intervention

1.33 (0.60-2.91)

0.69 (0.38-1.28)

0.63 (0.42-0.94)

25% (18-34)

Assertive community treatment

0.82 (0.43-1.54)

0.41 (0.12-1.44)

0.64 (0.30-1.37)

26% (14-42)

Rehabilitation

0.83 (0.24-2.85)

0.20 (0.07-0.62)

0.68 (0.37-1.24)

27% (17-40)

Relatives groups

0.66 (0.28-1.52)

0.53 (0.34-0.81)

0.71 (0.49-1.03)

28% (21-36)

Motivational interviewing

0.51 (0.29-0.90)

1.95 (0.75-5.05)

0.80 (0.36-1.74)

30% (16-48)

Case management

0.92 (0.30-2.85)

1.34 (0.16-11.31)

0.74 (0.42-1.31)

42% (8-86)

Treatment as usual

0.91 (0.60-1.39)

0.85 (0.47-1.57)

1 (1-1)

33% (24-43)

Health education

2.28 (0.35-15.01)

4.86 (0.63-37.25)

55% (16-89)

Family support

1.38 (0.44-4.33)

2.12 (0.80-5.63)

1.73 (0.44-6.81)

53% (30-75)

0.050.111020

≤ 6 months12 months> 12 months

Data table

Intervention	≤ 6 months	12 months	> 12 months	Event rate (95% CI)
Family intervention	0.63 (0.37-1.08)	0.35 (0.24-0.52)	,	16% (11-22)
Relapse prevention programme	0.39 (0.27-0.58)	0.41 (0.17-1.00)	0.33 (0.14-0.79)	15% (7-30)
Cognitive training	0.22 (0.05-0.88)	0.62 (0.10-3.99)	0.31 (0.07-1.40)	14% (4-43)
Cognitive behavioural therapy	0.34 (0.09-1.27)	0.57 (0.27-1.19)	0.45 (0.27-0.75)	20% (13-29)
Acceptance and commitment therapy	1.03 (0.54-1.97)	,	,	,
Supportive therapy	0.39 (0.13-1.16)	0.39 (0.12-1.27)	,	18% (6-41)
Family psychoeducation	0.53 (0.24-1.16)	,	,	22% (12-38)
Integrated intervention	1.07 (0.43-2.68)	0.68 (0.40-1.15)	0.56 (0.39-0.82)	23% (17-31)
Social skills training	0.42 (0.24-0.76)	0.45 (0.31-0.65)	0.62 (0.44-0.87)	25% (19-32)
Psychoeducation	0.49 (0.27-0.88)	3.55 (0.33-38.42)	0.62 (0.30-1.29)	25% (14-41)
Telemedicine intervention	1.33 (0.60-2.91)	0.69 (0.38-1.28)	0.63 (0.42-0.94)	25% (18-34)
Assertive community treatment	0.82 (0.43-1.54)	0.41 (0.12-1.44)	0.64 (0.30-1.37)	26% (14-42)
Rehabilitation	0.83 (0.24-2.85)	0.20 (0.07-0.62)	0.68 (0.37-1.24)	27% (17-40)
Relatives groups	0.66 (0.28-1.52)	0.53 (0.34-0.81)	0.71 (0.49-1.03)	28% (21-36)
Motivational interviewing	0.51 (0.29-0.90)	1.95 (0.75-5.05)	0.80 (0.36-1.74)	30% (16-48)
Case management	0.92 (0.30-2.85)	1.34 (0.16-11.31)	0.74 (0.42-1.31)	42% (8-86)
Treatment as usual	0.91 (0.60-1.39)	0.85 (0.47-1.57)	1 (1-1)	33% (24-43)
Health education	2.28 (0.35-15.01)	4.86 (0.63-37.25)	,	55% (16-89)
Family support	1.38 (0.44-4.33)	2.12 (0.80-5.63)	1.73 (0.44-6.81)	53% (30-75)

Odds ratios below 1 favour the experimental psychosocial intervention over treatment as usual. Wide confidence intervals reflect small trial numbers and should be interpreted cautiously.

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Psychosis Spectrum

Co-occurring Conditions

Psychosocial interventions: a meta-analysis

Visual representation (forest plot)

Data table

Psychosocial interventions: a meta-analysis

Visual representation (forest plot)

Data table

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